Eman Ahmed Abd El Aty, from Alexandria, Egypt, once weighed 1,100lbs, and before her surgery earlier this year had not left her house since she was 17.
Doctors at Burjeel Hospital in Abu Dhabi said Miss Ahmed Abd El Aty had died due to complications from her weight, including heart disease and kidney dysfunction.
Doctors blamed her weight on a thyroid condition, while her family claimed she suffered from elephantitis.
In March Miss Ahmed Abd El Aty was flown to Saifee Hospital in Mumbai, India, on a modified plane .She successfully underwent a gastric sleeve surgery and was reported in April to have lost 660 lbs – more than half of her bodyweight.
Miss Ahmed Abd El Aty arrived in the UAE in May, and was receiving care from a team of 20 doctors at Burjeel Hospital.